ACM SIGMETRICS Performance Evaluation Review · 2008 · 36 citations · 19 references
EngineeringSystems BiologyBiological Systems ModelingComputational BiologyComputational Systems BiologyComputational ModelingDynamic Systems ModelingMulti-scale Biological ModelingNetwork ModelingSignal Transduction ModelingComputational Biology ModelsComputational Pathway ModelingMitogen-activated Protein Kinase KinaseMitogen-activated Protein Kinase Pathway ActivationMitogen-activated Protein Kinase PathwaysPathway ModelingProcess CalculusSignaling Network Modeling
We introduce a scalable framework built upon the BlenX language and inspired by the Beta-binders process calculus to model, simulate and analyse biological systems. We show the features of the Beta Workbench framework on a running example based on the mitogen-activated kinase pathway. We also discuss an incremental modelling process that allows us to scale up from pathway to network modelling and analysis. We finally provide a comparison with related approaches and some hints for future extensions of the framework.
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Statecharts: a visual formalism for complex systems
David Harel · Science of Computer Programming · 1987 · 6.7K citations
COPASI—a COmplex PAthway SImulator
Stefan Hoops, Sven Sahle, Ralph Gauges et al. · Bioinformatics · 2006 · 2.7K citations · Full text