The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen et al. · Developmental Cell · 2006 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

Masato Koike, Masahiro Shibata, Masao Tadakoshi et al. · American Journal Of Pathology · 2008 · 487 citations · Full text

Medicine, Neurobiology, Neuroscience +12

NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy

Mojgan Djavaheri‐Mergny, Manuela Amelotti, Julie Mathieu et al. · Journal of Biological Chemistry · 2006 · 464 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +17

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Michael Degtyarev, Ann De Mazière, Christine Orr et al. · The Journal of Cell Biology · 2008 · 410 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

Ya-Dan Wen, Rui Sheng, Lisha Zhang et al. · Autophagy · 2008 · 391 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17