K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.7K citations

Tumor Biology, Somatic Variant, Tumor Heterogeneity +13

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Concepción Almoguera, Darryl Shibata, Kathleen Forrester et al. · Cell · 1988 · 2.1K citations

Pancreatic Cancer, Malignant Disease, Medicine +7

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

Ralph H. Hruban, A D van Mansfeld, G.J.A. Offerhaus et al. · PubMed · 1993 · 653 citations · Full text

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.

Mark Redston, Carlos Caldas, Albert Seymour et al. · PubMed · 1994 · 458 citations

Dna Microdeletions, Tumor Biology, Many Small Deletions +15

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

Christopher A. Moskaluk, Ralph H. Hruban, S E Kern · PubMed · 1997 · 433 citations

Genetics, Pathology, K-ras Gene Mutations +16