Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model

Statistical Methods in Medical Research.

C Wickham, P. Armitage, George Berry · Journal of the Royal Statistical Society Series A (Statistics in Society) · 1988 · 1.4K citations

Natural Sciences, Biostatistics, Mathematics +10

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

Medicine, Cardiology, Pharmacology +16

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

John M. Maraganore, P Bourdon, Jo-Ann Jablonski et al. · Biochemistry · 1990 · 468 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Improvement in early saphenous vein graft patency after coronary artery bypass surgery with antiplatelet therapy: results of a Veterans Administration Cooperative Study.

Steven Goldman, Jack G. Copeland, Thomas Moritz et al. · Circulation · 1988 · 431 citations

Medicine, Pharmacotherapy, Surgery +11

Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor.

M. Heras, James H. Chesebro, W J Penny et al. · Circulation · 1989 · 332 citations · Full text

Medicine, Cardiology, Hematology +16