Concepedia

An activated phosphate for an efficient amide and peptide coupling reagent

Tomohisa Yasuhara, Yasuo Nagaoka, Kiyoshi Tomioka

Journal of the Chemical Society Perkin Transactions 1 · 2000 · 14 citations · 19 references

DOI

Concepts

Abstract

Activation of diethyl phosphate was realized by attaching trifluoromethanesulfonanilide as an efficient leaving group and the phosphate 1 proved to be a promising amide and peptide coupling reagent.

References

19

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Louis A. Carpino · Journal of the American Chemical Society · 1993 · 1.5K citations

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J. H. Coste, Dung Le‐Nguyen, B. CASTRO · Tetrahedron Letters · 1990 · 614 citations

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<b>N-Hydroxysuccinimide Esters in Peptide Synthesis</b>

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Use of Onium Salt-Based Coupling Reagents in Peptide Synthesis<sup>1</sup>

Fernando Alberício, Josep María Bofill, Ayman El‐Faham et al. · The Journal of Organic Chemistry · 1998 · 268 citations

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