Molecular Oncology · 2008 · 47 citations · 39 references
Life SciencesCell BiologyOncologyCell ProliferationGene ExpressionMolecular OncologyCancer TranscriptomicsGene Fusions In CancerOncogene ActivationOncogenic ProliferationTranscription Factor OncogenesCell Proliferation KineticsDriver Fusion GenesLeukemia-associated Fusion GenesMouse Embryogenesis ModelsNucleolar FeaturesNucleolar OrganizationOncogenic Fusion ProteinsTumor-specific Fusion Genes
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
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