Cell Cycle · 2005 · 14 citations · 0 references
Life SciencesCell BiologyMolecular BiologyChromatin BiologyChromatin StructureDna RepairChromatinDna DamageDna Double-strand Break RepairDna Strand BreaksDouble-strand Break RepairHomologous RecombinationAtp-dependent Chromatin RemodelingChromatin Remodeling After Dna DamageChromatin Remodeling ComplexesDna Damage Repair PathwaysDna Strand Break RepairEnzymesHomologous Recombination RepairStructural Chromosomal Aberrations
The genomic integrity of a eukaryotic cell is challenged by over 10,000 chromosomal lesions per day. Therefore the cell has evolved efficient mechanisms to recognize, signal, and repair DNA breaks. Defects in any of these steps can lead to chromosomal aberrations and cancers. As these lesions must be repaired in the context of chromatin, both chromatin-modifying and nucleosome-remodeling enzymes have been implicated in DNA damage repair. We reported recently that the RSC and Swi/Snf ATP-dependent chromatin-remodeling complexes are involved in DSB repair specifically by homologous recombination. Here we discuss how such enzymes might be recruited to DNA breaks, why so many remodelers are recruited to sites of DSBs, and a possible functional connection between RSC's roles in sister chromatid cohesion and DSB repair.