Antitumor therapeutic effects of Salmonella typhimurium containing Flt3 Ligand expression plasmids in melanoma-bearing mouse

Tumor-targeted Salmonella as a novel anticancer vector.

John M. Pawelek, K. Brooks Low, David Bermudes · PubMed · 1997 · 527 citations

Medicine, Biotechnology, Oncology +12

Lipid A mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo

K. Brooks Low, Martina Ittensohn, Trung Bao Le et al. · Nature Biotechnology · 1999 · 476 citations

Life Sciences, Immunology, Microbiology +12

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

Donald Small, Mark E. Levenstein, Emily Kim et al. · Proceedings of the National Academy of Sciences · 1994 · 444 citations

Life Sciences, Hematology, Molecular Biology +12

Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines.

Kim Margolin, Anthony A. Rayner, Michael Hawkins et al. · Journal of Clinical Oncology · 1989 · 349 citations

Pharmacy, Immunology, Oncology +17

Flt3 ligand induces tumor regression and antitumor immune responses in vivo

David H. Lynch, Alice Andreasen, Eugene Maraskovsky et al. · Nature Medicine · 1997 · 313 citations

Medicine, Immunology, Oncology +14