Concepedia

Toward the Total Synthesis of Phorboxazole B: An Efficient Synthesis of the C20−C46 Segment

De Run Li, Cai Yun Sun, Ce Su, Guo‐Qiang Lin, Wei‐Shan Zhou

Organic Letters · 2004 · 20 citations · 55 references

Abstract

An efficient synthesis of the C20-C46 segment of phorboxazole B is described. The key steps involved Hg(OAc)(2)/I(2)-induced cyclization to construct the cis-tetrahydropyran moiety, the coupling of the metalated 2-methyloxazole 7 with lactone 6, and Julia olefination to furnish the conjugated diene moiety.

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