Publication | Open Access
Thyroid Receptor Ligands. 6. A High Affinity “Direct Antagonist” Selective for the Thyroid Hormone Receptor
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Citations
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References
2006
Year
Molecular PharmacologyVivo ExperimentBiochemistryMedicineHormonal ReceptorThyroid DiseaseReceptor (Biochemistry)Cell Transactivation AssayPharmacological AgentThyroid Receptor LigandsPharmacotherapyThyroid Hormone ReceptorDruglike PropertiesThyroid HormoneEndocrinologyPharmacologyDrug Discovery
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
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