Concepedia

Thyroid Receptor Ligands. 6. A High Affinity “Direct Antagonist” Selective for the Thyroid Hormone Receptor

Konrad F. Koehler, Sandra Gordon, Peter Brandt, Bo Carlsson, Anna Bäcksbro-Saeidi, T. Apelqvist, Peter Agback, Gary J. Grover, William Nelson, Marlena Grynfarb,

Journal of Medicinal Chemistry · 2006 · 37 citations · 17 references

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Concepts

Abstract

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

References

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