Nano Letters · 2011 · 219 citations · 53 references
MedicineCancer BiologyOncologyBiomedical ImagingDrug DeliveryMolecular ImagingCancer NanomedicineFluorescence ImagingInorganic NanoparticlesNanomaterials For Drug DeliveryNanomedicineTargeted Imaging AgentsCancer ImagingNanoparticle Imaging AgentsNanoparticle-based ProbesNanoparticle-mediated ImagingTargeted Molecular Imaging AgentsTargeted Optical ImagingTumor Vasculature TargetingZinc Oxide Nanostructures
Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
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In vivo cancer targeting and imaging with semiconductor quantum dots
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Renal clearance of quantum dots
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Catalytic Growth of Zinc Oxide Nanowires by Vapor Transport
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Natural Sciences, Materials Engineering, Materials Science +11