Hyperphosphatasia With Neurologic Deficit: A Pyridoxine-Responsive Seizure Disorder?

Mice lacking tissue non–specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B–6

Katrina G. Waymire, J. Dennis Mahuren, J. Michael Jaje et al. · Nature Genetics · 1995 · 404 citations

Medicine, Neurology, Neuroscience +12

Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization

Sonoko Narisawa, C. Wennberg, José Luís Millán · The Journal of Pathology · 2001 · 104 citations

Medicine, Neurology, Neuroscience +15

Areal and Subcellular Localization of the Ubiquitous Alkaline Phosphatase in the Primate Cerebral Cortex: Evidence for a Role in Neurotransmission

Caroline Fonta · Cerebral Cortex · 2004 · 103 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Highly sensitive and simple liquid chromatographic determination in plasma of B6 vitamers, especially pyridoxal 5′-phosphate

Mieko Kimura, Kazunori Kanehira, Katsuhiko Yokoi · Journal of Chromatography A · 1996 · 93 citations

Natural Sciences, Biochemistry, Chemistry +13

Familial hyperphosphatasia with mental retardation, seizures, and neurologic deficits

C. Charlton Mabry, Arturo Bautista, Richard F.H. Kirk et al. · The Journal of Pediatrics · 1970 · 73 citations

Medicine, Neurology, Pediatrics +15