Chemistry Letters · 1977 · 117 citations · 3 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganometallic ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsConjugate AdditionKetones
Abstract Trialkylzinclithium is readily prepared in THF by mixing zinc chloride (or its TMEDA complex) and alkyllithium in a 1 : 3 mole ratio. Conjugate addition of this new reagent is demonstrated with 2-cyclohexen-1-one (I) and dicyclopentadien-1-one (IV) as a,α,β-unsaturated ketones.
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