Stable industrial protease catalyzed peptide bond formation in organic solvent.

1. A - C

Eugen Reichel · 1909 · 1.5K citations

Computing, Computer Science, Differential Equations +1

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin

Jacques Fastrez, Alan R. Fersht · Biochemistry · 1973 · 192 citations

Life Sciences, Biochemistry, Molecular Biology +11

Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations

Chi Huey Wong, S.-T. Chen, William J. Hennen et al. · Journal of the American Chemical Society · 1990 · 178 citations

Life Sciences, Biochemistry, Molecular Biology +9

Using proteases in peptide synthesis

Kazuyuki Morihara · Trends in biotechnology · 1987 · 150 citations

Life Sciences, Biochemistry, Biocatalysis +8

Incorporation of D-amino acids into peptides via enzymic condensation in organic solvents

Alexey L. Margolin, Dar Fu Tai, Alexander M. Klibanov · Journal of the American Chemical Society · 1987 · 148 citations

Natural Sciences, Biochemistry, Chemistry +9