Organic Letters · 2002 · 38 citations · 17 references
Natural SciencesChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCarbonyl ChemistryCatalytic MechanismsCross-coupling ReactionsOrganic SynthesisAmino Carbonyl ReactionCarbonyl Rearrangement ReactionsCarbonylation ReactionsLewis Acid CatalysisLewis AcidityReaction Mechanism ElucidationRearrangement Reactions
A new Lewis acid promoted rearrangement reaction of 2,3-aziridino alcohols was discovered, which involved the highly stereoselective construction of a diastereogenic quaternary carbon center and efficient formation of beta-amino carbonyl compounds in excellent yields. A wide variety of Lewis acids were proved to be effective for the reaction, and a possible reaction mechanism was also discussed.
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