Early Blood Product and Crystalloid Volume Resuscitation: Risk Association With Multiple Organ Dysfunction After Severe Blunt Traumatic Injury

Abstract

When controlling for all major components of acute volume resuscitation, massive-transfusion volumes of PRBC's within the first 12 hours of resuscitation are modestly associated with MOD, whereas FFP and large volume crystalloid administration are not independently associated with MOD. Previous reported associations of blood products and large-volume crystalloid with MOD may be reflecting overall resuscitation requirements and burden of injury rather than independent causation.