Merging Oxidative Dearomatization and Aminocatalysis: One-Pot Enantioselective Synthesis of Tricyclic Architectures

Abstract

The combination of oxidative dearomatization and trienamine/enamine activation in a single vessel is described. Under these conditions, a three-bond forming process generates functionalized tricyclic architectures with up to six contiguous stereocenters with excellent stereoselectivities from readily available planar substrates.