The adipokine zinc‐α2‐glycoprotein (ZAG) is downregulated with fat mass expansion in obesity

Abstract

ZAG gene expression in adipose tissue is downregulated with increased adiposity and circulating insulin. ZAG mRNA is positively correlated with adiponectin mRNA, and ZAG enhances adiponectin production by human adipocytes. We suggest that ZAG is linked to obesity and obesity-related insulin resistance.