Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers

A New Substituent Constant, π, Derived from Partition Coefficients

Toshio Fujita, Junkichi Iwasa, Corwin Hansch · Journal of the American Chemical Society · 1964 · 1.4K citations

Natural Sciences, Chemistry, Analytical Chemistry +8

Structure-activity Relationships in the Development of Hypoxic Cell Radiosensitizers

G.E. Adams, Eric D. Clarke, I. R. Flockhart et al. · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1979 · 236 citations

Medicine, Pharmacology, Biochemical Pharmacology +14

Partition Coefficient as a Guide to the Development of Radiosensitizers Which Are Less Toxic Than Misonidazole

J. Martin Brown, Paul Workman · Radiation Research · 1980 · 215 citations

Medicine, Pharmacokinetics, Pharmacology +14

SR-2508: A 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use

Jeremy Brown, Ning Yu, Dennis Brown et al. · International Journal of Radiation Oncology*Biology*Physics · 1981 · 179 citations

Medicine, Medicinal Chemistry, Pharmacology +4

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo

G.E. Adams, I. Ahmed, P.W. Sheldon et al. · British Journal of Cancer · 1984 · 144 citations

Medicine, Oncology, Pharmacology +13