Journal of the American Chemical Society · 2002 · 209 citations · 13 references
MedicineCell BiologyMedicinal ChemistryBone MetabolismRegenerative MedicineStem Cell BiologyBone DevelopmentBone FormationBone RegenerationMesenchymal DifferentiationOsteoblast BiologyOsteogenesisCombinatorial Library ScreeningHigh-throughput Cell ScreeningMultipotent Progenitor CellsOsteoblast Lineage CommitmentOsteoblastic Lineage CellsOsteogenic DifferentiationProgenitor CellsPurine Analogs
Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
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Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine
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