Solubilized Gramicidin A as Potential Systemic Antibiotics

Abstract

Makeover of an old antibiotic: The channel-forming toxin gramicidin A (gA) has been successfully converted into agents that selectively chase after bacterial cells. These novel D-Lys-containing gA mutants display potent antimicrobial activity and remarkable therapeutic indexes (>1000-fold). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.