Science · 1972 · 45 citations · 7 references
PharmacyPharmacokineticsToxicologyPharmaceutical ToxicologyReproductive ToxicologyPrenatal ToxicityReproductive PharmacologyGestational ToxicologyPharmaceutical Exposure During PregnancyPharmaceutical TeratogenicitySurvival RatesTherapeutic Dose RangeTherapeutic Toxicity
Griseofulvin, a fungistatic agent, was administered in oral doses of 125 to 1500 milligrams per kilogramn per day to pregnant rats during organogenesis. Evaluation of the offspring from dams treated with the largest doses, 63 and 75 times a therapeutic dose in man, indicated decreased survival rates and a syndrome of malformations.
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Teratology. Principles and Techniques
Food and Cosmetics Toxicology · 1965 · 466 citations · Full text
Some Cytological Effects of Griseofulvin
Graham Paget, A. L. WALPOLE · Nature · 1958 · 132 citations
Biochemical Studies on the Metabolism of Griseofulvin
EARL G. Mc NALL · Archives of Dermatology · 1960 · 72 citations
Medicine, Dermatology, Pharmacology +11