Evidence that protein kinase C-α activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells

Expression of Multidrug Resistance Gene in Human Cancers

Lori J. Goldstein, Hanan Galski, Antonio Tito Fojo et al. · JNCI Journal of the National Cancer Institute · 1989 · 1.3K citations

Medicine, Cancer Biology, Oncology +11

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

Shin‐Ichi Osada, Keiko Mizuno, Takaomi C. Saido et al. · Journal of Biological Chemistry · 1990 · 428 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +9

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

Shin‐Ichi Osada, Keiko Mizuno, Takaomi C. Saido et al. · Molecular and Cellular Biology · 1992 · 337 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

Hiroyuki Nakanishi, John H. Exton · Journal of Biological Chemistry · 1992 · 284 citations · Full text

Life Sciences, Biochemistry, Biochemical Genetics +15

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

Ronald S. Weinstein, Shriram Jakate, José Miguel Domínguez et al. · PubMed · 1991 · 258 citations

Medicine, Oncology, Pharmacology +12