Concepedia

Publication | Closed Access

A target‐mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans

DOI

266

Citations

0

References

2002

Year

Stephen M. Eppler, Daniel L. Combs, Timothy D. Henry, John J. López, Stephen G. Ellis, Joo‐Hee Yi, Brian H. Annex, Edward R. McCluskey, Thomas F. Zioncheck
Clinical Pharmacology & Therapeutics

Abstract

This mechanism-based model accurately predicted VEGF concentrations and allowed for the simulation of various rhVEGF(165) dose regimens that may aid in optimization of drug delivery for future clinical trials.