Concepedia

Propylene Glycol Toxicity: A Severe Iatrogenic Illness in ICU Patients Receiving IV Benzodiazepines

Kevin C. Wilson, Christine C. Reardon, Arthur C. Theodore, Harrison W. Farber

CHEST Journal · 2005 · 170 citations · 22 references

Concepts

MedicinePharmacologyToxicologyCritical Care PharmacologyCritical Care PharmacotherapyNeurocritical CareDrug ToxicityNeurocritical Care PharmacologyPharmacodynamics In Critical IllnessPharmacokinetics In Critical IllnessSedative ToxicityBenzodiazepine ToxicityCritical Illness-related Altered PharmacokineticsPropylene Glycol ToxicitySevere Acute Illness

References

22

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult

Judith Jacobi, Gilles L. Fraser, Douglas B. Coursin et al. · Critical Care Medicine · 2002 · 1.9K citations

Nursing, Critical Care Nursing, Pharmacotherapy +16

Pharmacological Management of Alcohol Withdrawal

Michael F. Mayo‐Smith · JAMA · 1997 · 760 citations

Medicine, Pharmacology, Pharmacotherapy +17

Central nervous system toxicity associated with ingestion of propylene glycol

Karunyan Arulanantham, Myron Genel · The Journal of Pediatrics · 1978 · 109 citations

Pharmacy, Neuroscience, Toxicology +9

Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults*

Alejandro C. Arroliga, Nadine Shehab, Kevin McCarthy et al. · Critical Care Medicine · 2004 · 104 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +14

Propylene Glycol‐Associated Renal Toxicity from Lorazepam Infusion

Ndidi E. Yaucher, Jeffrey Fish, Heidi W. Smith et al. · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2003 · 93 citations

Pharmacy, Pharmacology, Toxicology +17