Archives of Dermatology · 1952 · 181 citations · 19 references
Veterinary MedicineOncologySurgeryCutaneous OncologySurgical OncologyTumor PathologyCutaneous NeoplasmsMalignant NeoplasmsMalignant TumorsSkin TumorsTumor InvasionTumor MorphologyCutaneous Blood VesselsFascial Planes AnatomyNeoplastic Cell MorphologyRoutes Of Cutaneous SpreadSkin Cancer HistopathologyTumor Cell Morphology
Over the past sixteen years, more than 3,000 cancers have been removed via microscopically controlled excisions (chemosurgery), revealing that many external cancers exhibit undetected irregular outgrowths. The study found that silent extensions of skin cancers follow specific tissue structures—dermis, fascial planes, periosteum, perichondrium, embryologic fusion planes, nerve sheaths, lymphatic and blood vessels—or, when no affinity exists, arise from local variations.
DURING the past sixteen years more than three thousand cancers have been removed by means of the microscopically controlled excisions which characterize the method which we have termed "chemosurgery."<sup>1</sup>A striking observation repeatedly made during the course of these excisions was that many external cancers exhibited irregular outgrowths which had not been detected by clinical visualization and palpation. In some cases these "silent" extensions were due to a peculiar affinity of the cancer for some specific tissue structure which it would follow selectively for unexpectedly great distances. Some structures for which certain cancers showed particular affinity were the following: (1) dermis, (2) fascial planes, (3) periosteum, (4) perichondrium, (5) embryologic fusion planes, (6) nerve sheaths, (7) lymphatic vessels, and (8) blood vessels. In other cases no specific affinities were observed, but nevertheless irregular outgrowths were present, apparently as a result of the countless local variations in
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Frederic E. Mohs · Archives of surgery · 1941 · 425 citations
The blood supply of nerves: I. Historical review.
Adams We · PubMed · 1942 · 109 citations
Medicine, Anatomy, Neurosurgery +14
CHEMOSURGICAL TREATMENT OF MELANOMA
Frederic E. Mohs · Archives of Dermatology and Syphilology · 1950 · 66 citations