Optimized NMR Spectroscopic Method for the Configurational Analysis of Chemically Equivalent Vicinal Protons

Abstract

Differentiating the identical: The measurement of homonuclear coupling constants of spins with identical chemical shifts (as observed in 1,2-disubstituted ethenes) provides important structural information, but its experimental realization is not trivial. A new method results in high sensitivity and simple spectra (see picture) that are easy to interpret. The underlying principle of this method is not limited to symmetric molecules with equivalent spins, but can also be applied to olefinic protons that have similar resonance frequencies.