Radical Cation Salt-Promoted Catalytic Aerobic sp³ C–H Oxidation: Construction of Quinoline-Fused Lactones and Lactams

Abstract

A direct construction of quinoline-fused lactones and lactams was achieved by sp(3) C-H bond oxidation of N-aryl glycine esters and amides under catalytic radical cation salt-induced conditions. These polycyclic products are formed in a single step from readily accessible starting materials, and this method provides a new synthetic approach to this class of heterocycles.