Asymmetric synthesis of (S)-camptothecin

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f].DELTA.6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin

Mansukh C. Wani, Allan W. Nicholas, Monroe E. Wall · Journal of Medicinal Chemistry · 1987 · 111 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Total synthesis of natural 20(S)-camptothecin

E. J. Corey, Dennis N. Crouse, Jerome E. Anderson · The Journal of Organic Chemistry · 1975 · 94 citations

Natural Sciences, Chemistry, Pharmacology +8