Diabetic neuropathy is associated with activation of the TNF‐α system in subjects with type 1 diabetes mellitus

Abstract

The activity of the TNF-alpha system is increased in subjects with type 1 diabetes mellitus and diabetic neuropathy, regardless of their glycaemic control and cardiovascular risk factors associated with insulin resistance. These results suggest that TNF-alpha may play a pathogenic role in the development of diabetic neuropathy.