Anesthesia & Analgesia · 1978 · 81 citations · 0 references
Life SciencesBiochemistryPharmacologyBiophysical ChemistryProtein-protein InteractionsProtein BindingAcid-base InteractionsPh DependencePh-dependent Binding KineticsPh-dependent Biomolecular Interactions
Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations.