Concepedia

Ph-dependent Binding Kinetics

pH-Dependent Binding Kinetics is a kinetic model in ligand binding theory that describes the rate and extent of molecular association or dissociation as a function of protonation states modulated by environmental pH, distinguishing it from pH-independent mechanisms by its explicit dependence on acid-base equilibria influencing binding affinity and reaction dynamics.

312

Publications

14.7K

Citations

1.1K

Authors

374

Institutions

Publications per year

2017–2026

30

Parents

Publications

312

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

Claire Davis, Joseph L. Goldstein, Thomas C. Südhof et al. · Nature · 1987 · 407 citations

, , +15

Re-Examination of the Apparent Binding Constant of Ethylene Glycol Bis(β-Aminoethyl Ether)-N,N,N',N'-Tetraacetic Acid with Calcium around Neutral pH12

Hikaru Harafuji, Yasuo Ogawa · The Journal of Biochemistry · 1980 · 397 citations

, , +15

Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity

Zhen Liu, Hui He · Accounts of Chemical Research · 2017 · 373 citations · Full text

, , +12

Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry

Brian M. Baker, Kenneth P. Murphy · Biophysical Journal · 1996 · 338 citations · Full text

, , +16

Anomalous Binding Profile of Phenylboronic Acid with<i>N</i>-Acetylneuraminic Acid (Neu5Ac) in Aqueous Solution with Varying pH

Hidenori Otsuka, Eiichiro Uchimura, Hiroyuki Koshino et al. · Journal of the American Chemical Society · 2003 · 322 citations

, , +17

1–5 of 312

Authors

1.1K

  1. QG
    Quentin Gibson

    Cornell University, United States

    9 publications · 337 citations

    9

    h-index

  2. MB
    Maurizio Brunori

    Sapienza University of Rome, Italy

    7 publications · 245 citations

    7

    h-index

  3. SH
    Simon H. de Bruin

    Radboud University Nijmegen, Netherlands

    5 publications · 86 citations

    5

    h-index

  4. PA
    Paolo Ascenzi

    Roma Tre University, Italy

    5 publications · 173 citations

    5

    h-index

  5. EA
    Eraldo Antonini

    Institute of Molecular Biology and Pathology, Italy

    5 publications · 200 citations

    5

    h-index

1–5 of 1.1K

Institutions

374

  1. Cornell University

    Ithaca, United States

    10 h-index

    20 publications

    741 citations

  2. University at Buffalo, State University of New York

    Buffalo, United States

    6 h-index

    17 publications

    737 citations

  3. Radboud University Nijmegen

    Nijmegen, The Netherlands

    5 h-index

    14 publications

    220 citations

  4. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    8 publications

    447 citations

  5. University of Illinois Chicago

    Chicago, United States

    4 h-index

    10 publications

    232 citations

  6. Uppsala University

    Uppsala, Sweden

    4 h-index

    10 publications

    447 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    14 publications

    359 citations

  8. University of Oslo

    Oslo, Norway

    4 h-index

    15 publications

    854 citations

1–8 of 374

Venues

  1. Journal of Biological Chemistry

    JBC · 58 publications · 3.2K citations

    34

    h-index

  2. Biochemistry

    18 publications · 872 citations

    16

    h-index

  3. European Journal of Biochemistry

    EJB · 17 publications · 428 citations

    13

    h-index

  4. Biochemical Journal

    BJ · 12 publications · 334 citations

    11

    h-index

  5. Environmental Science & Technology

    9 publications · 816 citations

    9

    h-index

1–5