Concepedia

Inconsistent Protective Efficacy and Marked Polymorphism Limits the Value of Schistosoma japonicum Tetraspanin-2 as a Vaccine Target

Wenbao Zhang, Jun Li, Mary Duke, Malcolm K. Jones, Ling Kuang, Jianfeng Zhang, David Blair, Yuesheng Li, Donald P. McManus

PLoS neglected tropical diseases · 2011 · 65 citations · 15 references

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Abstract

The highly polymorphic nature of the Sj-TSP-2 gene at the transcriptional level may limit the value of Sj-TSP-2 as a target for future S. japonicum vaccine development.

References

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Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis

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