Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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Life Sciences, Biochemistry, Molecular Biology +15

Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group · JAMA · 2000 · 1.5K citations

Pharmacy, Cardiology, Pharmacotherapy +16

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Henrik Daub, Christian Wallasch, Axel Ullrich · Nature · 1996 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +14

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

Louis M. Luttrell, Francine L. Roudabush, Eric W. Choy et al. · Proceedings of the National Academy of Sciences · 2001 · 818 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Masanori Asakura, Masafumi Kitakaze, Seiji Takashima et al. · Nature Medicine · 2002 · 718 citations

Life Sciences, Biochemistry, Cardiology +7