Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Erik H.F. Wong, J A Kemp, Tony Priestley et al. · Proceedings of the National Academy of Sciences · 1986 · 1.8K citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

Bradley V. Clineschmidt, Gregory E. Martin, Patricia R. Bunting · Drug Development Research · 1982 · 498 citations

Medicine, Neurology, Pharmacology +12

Antipsychotic Drugs, Neurotransmitters, and Schizophrenia

Arvid Carlsson · American Journal of Psychiatry · 1978 · 498 citations

Medicine, Pharmacology, Psychiatry +17

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

Maria Carlsson, Arvid Carlsson · Journal of Neural Transmission · 1989 · 426 citations

Life Sciences, Neuroscience, Pharmacology +16

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

Bradley V. Clineschmidt, Gregory E. Martin, Patricia R. Bunting et al. · Drug Development Research · 1982 · 230 citations

Medicine, Neuroscience, Pharmacology +17