The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Erik H.F. Wong, J A Kemp, Tony Priestley et al. · Proceedings of the National Academy of Sciences · 1986 · 1.8K citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

R. Gill, AC Foster, GN Woodruff · Journal of Neuroscience · 1987 · 643 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

Bradley V. Clineschmidt, Gregory E. Martin, Patricia R. Bunting · Drug Development Research · 1982 · 498 citations

Medicine, Neurology, Pharmacology +12

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

Patricia K. Sonsalla, William J. Nicklas, Richard E. Heikkila · Science · 1989 · 494 citations

Life Sciences, Neuroscience, Pharmacology +17

Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models

James O McNamara · Neuropharmacology · 1988 · 312 citations

Medicine, Neuroscience, Pharmacology +9