Angewandte Chemie International Edition · 1999 · 108 citations · 0 references
Natural SciencesChemistryAnalytical ChemistryElectroanalytical MethodsElectrochemistryIon SelectivityIon-selective ElectrodesLigand BindingProtein-ligand BindingProtein-ligand RecognitionStructural Basis Of RecognitionBiosensing With Ion-selective ElectrodesElectrode Ion AdsorptionHydrogen BondingIon Selective Electrode AnalysisIon Selective SensorsIonophore-based ElectrodesPotassium Ion Selective SensingPotassium Recognition
An ion-selective electrode (ISE) based on receptor 1 is highly selective for binding NH(4)(+) over K(+) (lg K(NH(4)(+)/K(+))=-2.6); the three imine nitrogen atoms in 1 are ideally positioned for hydrogen bonding with the tetrahedral NH(4)(+) ion. This selectivity is considerably greater than that found for commercial ISEs based on nonactin (lg K(NH(4)(+)/K(+))=-1.0).