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Influence of Testosterone Binding to Serum Proteins on Aromatization by Enzymes of Human Placental Microsomes
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1970
Year
Testosterone BindingHuman Placental MicrosomesReproductive HealthGynecologyFemale Reproductive FunctionReproductive BiologyReproductive EndocrinologySerum ProteinsPublic HealthMyometrial ContractilityPlacental DevelopmentVitro AromatizationAndrologyBiochemistryHormonal ReceptorMaternal HealthAromataseEndocrinologyPlacental FunctionDevelopmental BiologyPhysiologyPregnant Woman SerumMedicineEndocrine ResearchReproductive Hormone
In vitro aromatization of testosterone by human placental microsomes was delayed by binding testosterone to an “active protein fraction” purified from pregnant woman serum; this protein fraction was free of albumin and transcortin. The same inhibiting effect was observed when albumin was used as the testosterone binding protein but only with high concentrations of albumin.