Stereochemical Control in Microbial Reduction. XV. Preparation of (2<i>R</i>,3<i>S</i>)-2-Allyl-3-hydroxybutanoate

Abstract

Abstract The reduction of ethyl 2-allyl-3-oxobutanoate mediated by Mucor javanicus affords the corresponding (2R,3S)-syn-hydroxy ester. The stereoselectivity is excellent and complementary to the reduction mediated by bakers′ yeast where the (2S,3S)-anti-hydroxy ester is obtained.