Molecules · 2010 · 32 citations · 19 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryAmino Acid ChemistryCoordination ChemistryMetal CatalysisMetal-ligand BondingAmino Acid AmidesAryl Halide CouplingArylation ReactionsCarboxylate-ligand CatalysisCopper-catalyzed CouplingMild Reaction Conditions
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
19
Comprehensive medicinal chemistry
H. Timmerman, Aalt Bast, H. van der Goot et al. · Trends in Pharmacological Sciences · 1991 · 1.2K citations