Cleft Palate Is Caused by CNS Dysfunction in Gad1 and Viaat Knockout Mice

Abstract

Our results are consistent with a role for Gad1 and Viaat in the central nervous system for normal development of the palate. We suggest that the alterations in GABA signaling lead to non-neural defects such as cleft palate as a secondary effect due to alterations in or elimination of fetal movements.