Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia

Delayed neuronal death in the gerbil hippocampus following ischemia

Takaaki Kirino · Brain Research · 1982 · 2.9K citations

Life Sciences, Neurobiology, Neuroscience +14

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

Akira Kishimoto, K. Mikawa, Kenji Hashimoto et al. · Journal of Biological Chemistry · 1989 · 472 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

Robert Siman, J. Carl Noszek · Neuron · 1988 · 437 citations

Life Sciences, Neurobiology, Neuroscience +14

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

Rathna Nath, Kadee J. Raser, Daniel Stafford et al. · Biochemical Journal · 1996 · 427 citations · Full text

Life Sciences, Biochemistry, Neuroscience +13

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

JM Roberts-Lewis, MJ Savage, VR Marcy et al. · Journal of Neuroscience · 1994 · 320 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15