Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative

Banting lecture 1988. Role of insulin resistance in human disease

Gerald M. Reaven · Diabetes · 1988 · 3.8K citations

Medicine, Endocrinology, Physiology +11

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver et al. · Journal of Biological Chemistry · 1995 · 3.6K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Steven A. Kliewer, James M. Lenhard, Timothy M. Willson et al. · Cell · 1995 · 2K citations · Full text

Life Sciences, Biochemistry, Physiology +16

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

H. Keller, C Dreyer, Jeffrey A. Medin et al. · Proceedings of the National Academy of Sciences · 1993 · 949 citations

Life Sciences, Biochemistry, Molecular Biology +17

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and <i>ob/ob</i> Mice and Zucker Fatty Rats

Toshihiko Fujiwara, Shinji Yoshioka, Takao Yoshioka et al. · Diabetes · 1988 · 455 citations

Medicine, Endocrinology, Pharmacology +17