Nmr Assignments of Territrems A, B, and C and the Structure of MB₂, the Major Metabolite of Territrem B by Rat Liver Microsomal Fraction

Abstract

The 1H- and 13C-nmr assignments of territrems A, B, and C [1-3] were made by using nOe and 2D nmr techniques. Following the same methods, the structure of MB2 [4], the major product of territrem B incubated with rat liver microsomal fraction, was determined as a hydroxylation product at the pro S methyl group of C-4 of territrem B.