Concepedia

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells

Dong-Zhu Li, Qing-Xiang Zhang, Xiaoxian Dong, Huaidong Li, Xin Ma

Journal of Bone and Mineral Metabolism · 2013 · 56 citations · 34 references

References

34

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell · 2002 · 2.7K citations · Full text

Medicine, Cell Biology, Molecular Biology +16

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine · 2007 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +13

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Agamemnon E. Grigoriadis, Zhao‐Qi Wang, Marco Cecchini et al. · Science · 1994 · 1.3K citations

Medicine, Cell Biology, Molecular Genetics +17

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

Na Kyung Lee, Young Geum Choi, Ji Youn Baik et al. · Blood · 2005 · 952 citations · Full text

Medicine, Physiology, Bone Metabolism +14

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

I. Ross Garrett, Brendan F. Boyce, Richard O. C. Oreffo et al. · Journal of Clinical Investigation · 1990 · 815 citations · Full text

Medicine, Endocrinology, Bone Metabolism +15