Concepedia

A Newly Synthesized Poly(ADP-Ribose) Polymerase Inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: Pharmacological Profiles, Neuroprotective Effects, and Therapeutic Time Window in Cerebral Ischemia in Rats

Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, Toshifumi Hasegawa

Journal of Pharmacology and Experimental Therapeutics · 2005 · 56 citations · 30 references

DOI

Concepts

References

30

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

, , +17

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

Damien D’Amours, Serge Desnoyers, Icy D’Silva et al. · Biochemical Journal · 1999 · 1.8K citations · Full text

, , +9

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Seong-Woon Yu, Hongmin Wang, Marc F. Poitras et al. · Science · 2002 · 1.8K citations

, , +15

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Mikael J. L. Eliasson, Kenji Sampei, Allen S. Mandir et al. · Nature Medicine · 1997 · 1K citations

, , +14

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

Hyo Chol Ha, Solomon H. Snyder · Proceedings of the National Academy of Sciences · 1999 · 907 citations · Full text

, , +15