Ultrastructure of ovarian tumors.I. Papillary serous cystadenocarcinoma

Abstract

Twenty-eight cases of papillary serous cystadenocarcinoma are evaluated by light and electron microscopy. Five cell types are commonly identified in these tumors. Cell types A and B are similar to those seen in the upper female genital tract (fallopian tube). Cell type C is similar to the responding cell of the endometrium. Cell type D is composed of two secretory types of cells, one resembling endocervical epithelium. Cell type E is of an unusual cell type not compatible with any cell previously seen in the female genital tract by the authors. These findings support the hypothesis that these tumors (and other cystomas) are derived from “germinal epithelium.” Findings common to other tumor cells are identified including annulate lamellae, unusual appearing mitochondria, numerous free polyribosomes, large irregular nuclei with macronucleoli, and nuclear inclusions.