Concepedia

Ammonia impairs neutrophil phagocytic function in liver disease†

Debbie L. Shawcross, Gavin Wright, Vanessa Stadlbauer, Stephen Hodges, Nathan Davies, Caroline Wheeler‐Jones, Andrew A. Pitsillides, Rajiv Jalan

Hepatology · 2008 · 164 citations · 32 references

DOIFull text

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Abstract

Ammonia produces neutrophil swelling and impairs neutrophil phagocytosis. The p38(MAPK) intracellular signaling pathway has been shown to be important in mediating the ammonia-induced neutrophil dysfunction.

References

32

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

I. Vermes, C. Haanen, H M Steffens-Nakken et al. · Journal of Immunological Methods · 1995 · 5.3K citations · Full text

, , +9

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Séamus J. Martin, Chris Reutelingsperger, Anne J. McGahon et al. · The Journal of Experimental Medicine · 1995 · 2.8K citations · Full text

, , +20

Bacterial infections in cirrhosis: Epidemiological changes with invasive procedures and norfloxacin prophylaxis

Javier Fernández, Miquel Navasa, J Gómez et al. · Hepatology · 2002 · 949 citations · Full text

The systemic inflammatory response syndrome in acute liver failure

Nancy Rolando, Jim Wade, Milagros Dávalos et al. · Hepatology · 2000 · 721 citations · Full text

, , +21

Cerebral Herniation in Patients With Acute E Liver Failure Is Correlated With Arterial Ammonia Concentration

Jens Otto Clemmesen, Fin Stolze Larsen, Jens Kondrup et al. · Hepatology · 1999 · 664 citations · Full text

, , +14