Secalonic acid D blocks embryonic palatal mesenchymal cell‐cycle by altering the activity of CDK2 and the expression of p21 and cyclin E

Abstract

These results suggest that the S-phase-specific cell-cycle proteins CDK2, cyclin E and possibly p21 are the common targets of SAD in murine palatal shelves in vivo and in human embryonic palatal mesenchymal cells in vitro and may be relevant to the pathogenesis of SAD-induced CP.