Concepedia

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

Jérôme Parcq, Thomas Bertrand, Axel Montagne, A F Baron, Richard Macrez, Jean‐Marie Billard, Aurélien Briens, Yannick Hommet, Jialing Wu, Manuel Yepes,

Cell Death and Differentiation · 2012 · 67 citations · 36 references

DOI

Concepts

References

36

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

Petti T. Pang, Henry Teng, Eugene Zaitsev et al. · Science · 2004 · 1.1K citations

, , +12

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

Zhuo Qian, Mary E. Gilbert, Michael A. Colicos et al. · Nature · 1993 · 866 citations

, , +11

Glutamate neurotoxicity in cortical cell culture is calcium dependent

Dennis W. Choi · Neuroscience Letters · 1985 · 815 citations

, , +16

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling

Olivier Nicole, Fabián Docagne, Carine Ali et al. · Nature Medicine · 2001 · 723 citations

, , +16

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

Stella E. Tsirka, Anna Gualandris, David G. Amaral et al. · Nature · 1995 · 656 citations

, , +14